Little Sister

How to play Little Sister by Queens of the Stone Age on guitar

These are the sounding chords. With a capo on fret 6 you play D, Dm, A#, G, C, A and more, the shapes the player above shows.

Little Sister is a tight, driving rock tune that feels punchy and fun once you lock into the groove. At about 120 BPM, it rewards clean changes and steady time, so you get a strong, riff-like feel without needing a lot of extra flash.

The chart starts with G# - G#m - E - C#, so you will move between a mix of open and barre shapes. The harder grips are G#, G#m, C#, F#, D#, D#m, and B, while E and D are open. Watch the shift from G# to G#m closely, since that small change can throw off your hand if you rush it.

Start by looping the opening progression slowly and making each chord ring clearly. Then practice the barre shapes on their own, add the open chords, and only after that bring the whole sequence up to tempo. Once the changes feel automatic, play along with the beat and focus on staying relaxed.

Use the play-along above to follow each chord change in time with the music, or learn the shapes first with the chord diagrams below.